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KMID : 0191120120270020221
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Journal of Korean Medical Science
2012 Volume.27 No. 2 p.221 ~ p.224
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Severe Osteomyelitis as a Complication of Tokyo-172 BCG Vaccination
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Kwon Hyo-Jin
Chung Bo-Hyun
Choi Byung-Min
Park Kyung-Un
Kim Yun-Kyung
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Abstract
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The bacilli Calmette-Guerin (BCG) Tokyo-172 strain was considered to exhibit good protective efficacy with a low rate of unfavorable side effects. However, we describe a rare case of BCG osteomyelitis developed in an immunocompetent host who was given with BCG Tokyo-172 vaccine on the left upper arm by multipuncture method. A 9-month-old girl presented with progressive inability to move her right elbow and had radiographic evidence of septic elbow combined with osteomyelitis of right distal humerus. A biopsy from the site revealed chronic caseating granulomatous inflammation, positive for BCG Tokyo-172 strain on the multiplex polymerase chain reaction. The child had to undergo second surgical debridements and oral antituberculosis chemotherapy. There were no sequelae after 2 yr of follow-up. This complication, although uncommon, should be considered in the appropriate clinical setting.
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KEYWORD
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Osteomyelitis, Complication, Bacilli Calmette-Guerin Vaccination
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